Active learning traditionally assumes that an oracle is capable of providing labeling information for each query instance. This paper formulates a new research problem which allows an oracle admit that he/she is incapable of labeling some query instances or simply answer "I don't know the label." We define a unified objectivefunction to ensure that each query instance submitted to the oracleis the one mostly needed for labeling and the oracle should also hasthe knowledge to label. Experiments based on different types of knowledge blind spot (KBS) models demonstrate the effectiveness of theproposed design.

In this model, each training example is a set (or bag) of instances along with a single label equal to the maximum label among all instances in the bag. The individual instances within the bag are not given labels. The goal is to learn to accurately predict the label of previously unseen bags. Standard supervised learning can be viewed as a special case of MI learning where each bag holds a single instance. The MI learning model was originally motivated by the drug activity prediction problem where each instance is a possible conformation (or shape) of a molecule and each bag contains all likely low-energy conformations for the molecule.

In this model, each training example is a set (or bag) of instances along with a single label equal to the maximum label among all instances in the bag. The individual instances within the bag are not given labels. The goal is to learn to accurately predict the label of previously unseen bags. Standard supervised learning can be viewed as a special case of MI learning where each bag holds a single instance. The MI learning model was originally motivated by the drug activity prediction problem where each instance is a possible conformation (or shape) of a molecule and each bag contains all likely low-energy conformations for the molecule.

We present a new multiple-instance (MI) learning technique (EM DD) that combines EM with the diverse density (DD) algorithm. EM-DD is a general-purpose MI algorithm that can be applied with boolean or real-value labels and makes real-value predictions. On the boolean Musk benchmarks, the EM-DD algorithm without any tuning significantly outperforms all previous algorithms. EM-DD is relatively insensitive to the number of relevant attributes in the data set and scales up well to large bag sizes. Furthermore, EM DD provides a new framework for MI learning, in which the MI problem is converted to a single-instance setting by using EM to estimate the instance responsible for the label of the bag. 1 Introduction The multiple-instance (MI) learning model has received much attention.

Multiple-instance learning is a variation on supervised learning, where the task is to learn a concept given positive and negative bags of instances. Each bag may contain many instances, but a bag is labeled positive even if only one of the instances in it falls within the concept. A bag is labeled negative only if all the instances in it are negative. We describe a new general framework, called Diverse Density, for solving multiple-instance learning problems. We apply this framework to learn a simple description of a person from a series of images (bags) containing that person, to a stock selection problem, and to the drug activity prediction problem.

Multiple-instance learning is a variation on supervised learning, where the task is to learn a concept given positive and negative bags of instances. Each bag may contain many instances, but a bag is labeled positive even if only one of the instances in it falls within the concept. A bag is labeled negative only if all the instances in it are negative. We describe a new general framework, called Diverse Density, for solving multiple-instance learning problems. We apply this framework to learn a simple description of a person from a series of images (bags) containing that person, to a stock selection problem, and to the drug activity prediction problem.

Multiple-instance learning is a variation on supervised learning, where the task is to learn a concept given positive and negative bags of instances. Each bag may contain many instances, but a bag is labeled positive even if only one of the instances in it falls within the concept. A bag is labeled negative only if all the instances in it are negative. We describe a new general framework, called Diverse Density, for solving multiple-instance learning problems. We apply this framework to learn a simple description of a person from a series of images (bags) containing that person, to a stock selection problem, and to the drug activity prediction problem.